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CelaCare’s unique technology is based on the strong antimicrobial synergism between silver citrate used in its products and acemannan derived from Aloe vera L. This synergism enables substantial reductions in the levels of silver required, which translates into improved products with superior skin feel. The combination of these two compounds together with other components in CelaCare’s proprietary formulations creates the basis for products that aid in healing and management of diverse types of wounds. A pending patent with the United States Patent Office as well as the European Patent Office protects CelaCare’s technology providing broad worldwide protection.

Silver citrate

aloespoon


Silver salts are used in a number of topical antimicrobial products. The mechanism of action involves the binding of ionic silver to microbial proteins, causing structural changes in cell walls and intracellular and nuclear membranes. Silver has also been shown to bind directly to DNA and RNA, denaturing nucleotides and thereby inhibiting replication. Silver citrate used in CelaCare formulations act as a potent antimicrobial agent with bactericidal and fungicidal properties against both non-resistant and antibiotic resistant organisms such as antibiotic resistant Staphylococcus.

CelaCare’s formulations use a proprietary form of silver citrate that enables the development of diverse formulations with superior characteristics. The concentration of silver citrate used in CelaCare Antimicrobial Wound Gel as well as future planned products is significantly below levels that would cause discoloration of the skin. more

Acemannan

acemannan

Acemannan is a complex mixture of high molecular weight carbohydrates purified from Aloe vera L. also known as Aloe vera barbadensis Miller. The inner clear mucilage gel of Aloe vera, referred to as Aloe vera gel, has been used for centuries to treat and manage wounds. Aloe vera gel contains a variety of chemical substances with the principal component being a large molecular weight complex carbohydrate, identified and given the United States Adopted Name, acemannan. Multiple properties have been attributed to acemannan but the most predominant have been its immune regulatory functions. Included as part of these functions is the ability of acemannan to stimulate release of primary growth factors necessary for optimal and accelerated wound healing. There is also some evidence that acemannan may interfere with adherence of bacteria to epithelial cells. In addition to its immune modulation activities, acemannan has also been shown to have anti-inflammatory properties and aid in the control of pain. more

Synergy of Acemannan and Silver Citrate

Both silver citrate and acemannan formulate well with a number of ingredients, providing flexibility for CelaCare’s formulation chemists. Once formulated, a resulting product is designed to have activity against both sensitive and antibiotic resistant microorganisms as well as to impart desired effects to optimize healing. The number of resistant organisms is becoming very problematic with serious therapeutic complications being observed especially with Staphylococcus aureus and Pseudomonas aeruginosa. more